Google
Trusted Resources: Evidence & Education
Scientific literature and patient education texts
Cerebral haemorrhagic risk in children with sickle-cell disease
source: Developmental Medicine & Child Neurology
year: 2015
authors: Kossorotoff M, Brousse V, Grevent D, Naggara O, Brunelle F, Blauwblomme T, Gaussem P, Desguerre I, De Montalembert M
summary/abstract:AIM:
To address risk of first or recurrent cerebral haemorrhage in children with sickle-cell disease (SCD) who are being managed with modern stroke prevention strategies.
METHOD:
A systematically followed SCD paediatric cohort was retrospectively studied over a 9-year period. Haemorrhagic risk was defined as intracranial haemorrhage occurrence or intracranial aneurysm diagnosis during the study period. Ischaemic risk was defined as cerebrovascular ischaemic event occurrence or transcranial Doppler/magnetic resonance imaging hallmarks of ischaemic risk finding during the study period.
RESULTS:
Among the 251 patients in the cohort, 36 patients were included in the ischaemic group. Seven patients were included in the haemorrhagic group, of which five also met the criteria for the ischaemic group. Age at first haemorrhagic symptom/hallmark of risk was older (10.4 vs 6.2 years old, p=0.036). Nine intracranial saccular aneurysms were found, mostly on the posterior circulation. Two patients had endovascular embolization.
INTERPRETATION:
The ratio of ischaemic to haemorrhagic risk was not modified with modern management compared with historical series. Intracranial aneurysm in children with SCD had specific characteristics, close to intracranial aneurysms described in adults with SCD. Data favoured concurrent development of intracranial SCD-associated anterior stenosis and posterior dilation, suggesting common pathophysiology and management strategies.
DOI: 10.1111/dmcn.12571
read more full text
+myBinderRelated Content
-
Cardiomyopathy With Restrictive Physiology in Sickle Cell DiseaseOBJECTIVES: The aim of this study was to...
-
Marijuana Use and Health Behaviors in a US Clinic Sample of Patients With Sickle Cell DiseaseIntroduction: As marijuana use becomes ...
-
APS Scientific Meeting 2019The American Pain Society will hold its ...
-
Today’s Faces of Sickle Cell Disease: Jennelle StephensonJennelle Stephenson was diagnosed with S...
-
Today’s Faces of Sickle Cell Disease: Tesha SamuelsTesha Samuels was diagnosed with SCD at ...
-
Sickle Cell and Young Stroke SurvivorsSickle Cell & Young Stroke Survivors...
-
Dr. Doris Wethers, 91, on Front Lines against Sickle Cell, DiesDr. Doris L. Wethers, who broke racial b...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More Information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.
Powered by
SomeBodyToTalkTo connects people affected by rare diseases with trusted resources, supportive communities, and opportunities to share their experiences.