Sickle Cell Disease news and research updates
Research readouts, treatment and access decisions, and community updates for people living with sickle cell disease and the people who care for them — each one dated, with a link to the original source where there is one.
183 articles match your filtersFree, no login required
Looking for earlier coverage? Browse the news archive.
Nonmyeloablative and reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation in sickle cell disease: a narrative review of safety, engraftment, and graft-versus-host-disease outcomes in adults and high-risk populations
Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) is the only widely available cure for sickle cell disease (SCD), yet its use in adults has historically been…
Incidence of clinical malaria and asymptomatic parasitaemia among African children living with sickle cell disease: a multicentre prospective longitudinal cohort study protocol
Abstract Introduction Sickle cell disease is a monogenic blood disorder prevalent in Africa, where malaria poses a health risk for affected individuals. Individuals with sickle…
Premature blood stem cell aging in sickle cell disease may be reversible
Scientists at St. Jude Children’s Research Hospital found that prematurely old blood stem cells from sickle cell disease may be treatable with anti-aging drugs, and highlight a…
Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Sickle Cell Disease
A promising approach for the treatment of genetic diseases is called gene therapy. Gene therapy is a relatively new field of medicine that uses genetic material (mostly DNA) from…
Doctors misjudge SCD clinical trial motivations, US study finds
Suggestions target more effective communication to boost patient participation In the U.S., doctors who care for people with sickle cell disease (SCD) often don’t have a clear…
Distinct prokaryotic gut microbiome and proviral-immune axes of pathophysiology in Sickle Cell Disease
Sickle cell disease (SCD) is a chronic, inherited condition rising across the globe. Prior studies revealed a direct link between the gut microbiome and disease micropathology via…
Hydroxyurea and Gut Microbiome Interactions in Sickle Cell Disease: Toward Adjunctive Microbiome-based Therapy
Abstract Sickle cell disease (SCD) is a monogenic disorder marked by hemoglobin S polymerization, resulting in chronic hemolysis, vaso-occlusion, systemic inflammation, and…
Trial Tests a New Gene-Editing Strategy for Sickle Cell Disease
The multicenter trial is evaluating a CRISPR-Cas9 approach designed to directly modify the beta‑globin gene in sickle cell disease. FDA-approved gene therapies have shown that…
Cardiac Remodeling Patterns in Pediatric and Adolescent Patients with Sickle Cell Disease and Their Association with the Genotype and Clinical Severity of the Disease: A Systematic Review
Abstract Background: Sickle cell disease (SCD) is the most common inherited blood disorder globally, affecting approximately 300,000 newborns annually. Cardiac remodeling…
Alloimmunization among Multiply Transfused Pediatric Patients with Sickle Cell Disease Attending Jaramogi Oginga Odinga Teaching and Referral Hospital, Kenya
Abstract Background: Sickle cell disease (SCD) is a major inherited haemoglobin disorder and a leading cause of childhood morbidity and mortality in sub-Saharan Africa. Repeated…
Blood Rheology After Allogeneic Hematopoietic Stem Cell Transplantation or Gene Therapy in Sickle Cell Disease
Abstract Allogeneic hematopoietic cell transplantation (HCT) and autologous hematopoietic stem cell–based gene therapies are potentially curative for sickle cell disease (SCD)…
Platelet Indices as Accessible Biomarkers for Risk Stratification in Pediatric Sickle Cell Disease: A Kenyan Cohort Study
Main Points High MPV and neutrophils with low PNR may act as accessible hematological signatures for VOC and ischemic stroke in pediatric SCD. Platelet indices could serve as…