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Randomized Trials Needed to Assess Benefits of Salmonella Vaccines in SCD Patients, Study Says

Randomized controlled trials are needed to examine the benefits of vaccinating people with sickle cell disease (SCD) against salmonella infections, which can be particularly fatal to children with the disease, a study says.

The review study, “Vaccines for preventing invasive salmonella infections in people with sickle cell disease,” was published in the Cochrane Database of Systematic Reviews.

Among people with SCD, mortality is highest in children, with a rate of between 2 percent and 30 percent in the first five years of life. Many of these deaths are caused by severe infections, to which children with SCD are more susceptible.

The sickle shape of SCD red blood cells makes them more prone to getting stuck inside small blood vessels, including in the spleen, which can block the blood flow through this organ and cause a condition referred to as splenic sequestration.