• Join Today!

Become a member and connect with:

  • An Active Online Community
  • Articles and Advice on SCD
  • Help Understanding Clinical Trials
abstracts & posters

Vasopressin SNP is related to sickle cell acute care utilization for pain

key information

source: The Journal of Pain

year: 2016

authors: K. Roach, E. Jhun, Y. He, M. Suarez, Y. Yao, R. Molokie, Z. Wang, D. Wilkie


Patients suffering from sickle cell disease (SCD) commonly have varying degrees of chronic debilitating pain and episodic acute pain. The variability is broad even between individuals with the same genotype. In this study, the AVPR1A polymorphism was explored to investigate the contribution of gene polymorphisms to variations in pain for individuals with SCD. The sample of 115 individuals (mean age 34.1 +/- 12.3 [range 15-70 years], 68% female) was 97% African American with SCD (81% SS, 10% SC, 9% other). From electronic health record review and bi-weekly telephone calls with subjects, we determined each patient’s utilization of emergency and acute care services (mean 4.4, SD 5.4 [range from 0 to 38 visits]) as an indicator for acute SCD pain. At a routine clinic visit, patients completed PAINReportIt to obtain the Composite Pain Index (CPI) as an indicator of chronic pain (mean 40.7, SD 13.6, [ranged 14.8 to 86.5]) and we obtained blood samples. We performed genotyping on SNP rs10877969 and found that there were 35 with CC genotype, 45 with CT genotype, and 34 with TT genotype (1 subject’s genotype was unknown). Negative binomial regression of patient utilization found that, controlling for age, sex, and SCD type, subjects with either CC or CT genotype had significantly higher utilization than those with TT genotype (p=0.026). This SNP was not a significant predictor for CPI in this study. In previous studies of SNPs related to AVPR1a, analgesia effects were found to be dependent on both stress and sex. This is the first study to show that this SNP (rs10877969) is significantly related to acute SCD pain, a pain condition also associated with stress and inconsistent findings related to sex. Additional research is needed to further examine the influence of the SNP rs10877969 on pain outcomes.

organization: University of Illinois at Chicago

DOI: 10.1016/j.jpain.2016.01.149

read more

expertly curated content related to this topic

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.