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scientific articles

Efficacy and safety of ledipasvir/sofosbuvir for the treatment of chronic hepatitis C in persons with sickle cell disease

key information

source: Clinical Infectious Diseases

year: 2017

authors: Moon J, Hyland RH, Zhang F, Brainard DM, Lanzkron S, McHutchison JG, Sulkowski M


Patients with sickle cell disease are at high risk for chronic hepatitis C infection. Prior treatment has been limited due to the use of ribavirin causing hemolytic anemia and interferon causing cytopenias. We demonstrate the safety and efficacy of fixed dose combination, ledipasvir and sofosbuvir for 12 weeks in this population.

organization: Johns Hopkins University School of Medicine, Baltimore; Gilead Sciences, Inc., Foster City USA

DOI: 10.1093/cid/cix441

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