• Join Today!

Become a member and connect with:

  • An Active Online Community
  • Articles and Advice on SCD
  • Help Understanding Clinical Trials
scientific articles

Similar Burden of Type 2 Diabetes Among Adult Patients With Sickle Cell Disease Relative to African Americans in the U.S. Population: A Six-Year Population-Based Cohort Analysis

key information

source: British Journal of Haematology

year: 2019

authors: Zhou J, Han J, Nutescu EA, Galanter WL, Walton SM, Gordeuk VR, Saraf SL, Calip GS

summary/abstract:

Conflicting evidence exists on the epidemiology of type 2 diabetes mellitus (T2DM) among patients with sickle cell disease (SCD). This study measured the prevalence, incidence and clinical outcomes associated with T2DM in a large US population of commercially-insured adults aged >=20 years with SCD between 2009 and 2014. Among 7070 patients with SCD, the mean age (median) was 39 (37) years and 60•8% were female. The standardized prevalence of T2DM among patients with SCD showed a modest increase, from 15•7% to 16•5% (P trend = 0•026), and was comparable to African-American respondents to the National Health and Nutrition Examination Survey (18•2%). Over 17 024 person-years, the crude incidence rate for T2DM was 25•4 per 1000 person-years. Incident T2DM was associated with comorbid hypertension (hazard ratio [HR] = 1•45, 95% confidence interval [CI] 1•14-1•83), and dyslipidaemia (HR = 1•43, 95%CI 1•04-1•96). Compared to SCD patients without T2DM, more SCD patients with T2DM had diagnoses of nephropathy (28•0% vs. 9•5%; P < 0•001), neuropathy (17•7% vs. 5•2%; P < 0•001) and stroke (24•1% vs. 9•2%; P < 0•001). Prevalence of T2DM in SCD patients is similar to the general African American population with an increasing trend in recent years. These trends support routine screening for T2DM in aging patients with SCD, especially those with comorbid hypertension and/or dyslipidaemia.

organization: University of Illinois at Chicago, USA; Fred Hutchinson Cancer Research Center, USA

DOI: 10.1111/bjh.15773

read more

expertly curated content related to this topic

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences. More information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close