Trusted Resources: Evidence & Education
Scientific literature and patient education texts
The role of blood rheology in sickle cell disease
source: Blood Reviews
authors: Connes P, Alexy T, Detterich J, Romana M, Hardy-Dessources MD, Ballas SKsummary/abstract:
Studies performed in the last decades have highlighted the need to better understand the contribution of the endothelium, vascular function, oxidative stress, inflammation, coagulation, hemolysis and vascular adhesion mechanisms to the pathophysiology of acute vaso-occlusive like events and chronic organ damages in sickle cell disease (SCD). Although SCD is a hemorheological disease, a few works focused on the contribution of blood viscosity, plasma viscosity, red blood cell deformability and aggregation in the pathophysiology of SCD. After a brief description of basic hemorheology, the present review focuses on the role of the hemorheological abnormalities in the causation of several SCD complications, mainly in sickle cell anemia and hemoglobin (Hb) SC disease. Several genetic and cellular modulators of blood rheology in SCD are discussed, as well as unresolved questions and perspectives.organization: Inserm UMR; Laboratory of Excellence GR-Ex; Institut Universitaire de France, Paris, France; Laboratoire CRIS EA647, Section "Vascular Biology and Red Blood Cell", Université Claude Bernard Lyon; Emory University School of Medicine, Atlanta; Children's Hospital Los Angeles; Cardeza Foundation for Hematologic Research, Jefferson Medical College, Thomas Jefferson University, Philadelphia
read more full text
Venous thromboembolism in adults screened for sickle cell trait: a population-based cohort study with nested case-co...OBJECTIVE: To determine whether sickle ...
Fighting Through Our Pain TV with Thomas J. Harrington MDhttps://www.youtube.com/watch?time_conti...
Acute chest syndrome among hospitalized children with vaso-occlusive crisis: A nationwide study in the United StatesBackground: Acute chest syndrome (ACS) r...
CTX001 Continues to Show Promise in Severe SCDA single dose of CTX001, an experimental...
Living With Sickle Cell Disease Is a Constant Battle With Pain, According to one Woman Who Has It“You don’t look sick.” That’s ...
Preventing Strokes in Children with Sickle Cell Diseasehttps://www.youtube.com/watch?v=k6h7cb7S...
Living With Unpredictable Pain: A Sickle Cell Disease StoryGrowing up, Vismel Marquez wanted to joi...
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.