Sickle Cell Disease news and research updates
Research readouts, treatment and access decisions, and community updates for people living with sickle cell disease and the people who care for them — each one dated, with a link to the original source where there is one.
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Cure Sickle Cell Initiative recommendations on common data elements for sickle cell disease gene therapy trials
Abstract The Cure Sickle Cell Initiative (CureSCi), created by the National Heart, Lung, and Blood Institute, has developed data standards to increase interoperability and…
Thrombocytosis and the generation of platelet-derived microparticles in the pathophysiology of sickle cell disease
Summary Sickle cell disease (SCD) is a complex thrombo-inflammatory disorder in which haemolysis, platelet activation, thrombocytosis, inflammation and endothelial activation…
Genetic variants in red blood cell adhesion-related genes influence the severity of sickle cell anemia in a malaria-endemic region : Short title: Genetic variants in red blood cell adhesion-related genes in sickle cell anemia
Abstract Background: Sickle cell anemia (SCA) is a genetic disease marked by abnormal hemoglobin S and sickle-shaped red blood cells. It is highly prevalent in sub-Saharan Africa…
Beyond the Diagnosis: Lived Experiences of People with Sickle Cell Disease in South India
Abstract Background Sickle cell disease (SCD) is an inherited blood disorder characterized by the presence of sickle-shaped erythrocytes, leading to haemolytic anemia…
Rethinking the cost of curing sickle cell disease
Gene therapies for sickle cell disease are already changing lives in high-income countries, but in places like Uganda—where the burden of disease is among the highest in the…
Ten Years of Hydroxyurea for Ugandan Children with Sickle Cell Anemia
Sickle cell anemia is a severe inherited hemoglobinopathy with a large global burden, particularly in sub-Saharan Africa. 1 Hydroxyurea, which is standard therapy for sickle cell…
Subclinical malaria in sickle cell disease in Northern Uganda: prevalence, predictors, and hematologic impact
Abstract Objectives Sickle Cell Disease (SCD), characterized by persistently low hemoglobin (Hb) and hematocrit levels, is among the leading causes of under-five mortality in high…
Hyperbaric Oxygen Therapy in Sickle Cell Disease: A Narrative Review of Mechanisms, Clinical Applications, and Future Directions
Abstract Sickle cell disease (SCD) is characterized by recurrent vaso-occlusion, hemolysis, and chronic inflammation, leading to acute painful crises and progressive organ damage…
Oral Radiographic Changes in Severe Sickle Cell Anemia Patients: A Retrospective Comparative Study
Haifa AlKhodier, Fahad Bin Saleh, Abdulmajeed AlRumi, Tariq AlOjaym Department of Dentistry, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia…
Natural History of Sickle Cell Disease
Study Overview Brief Summary This study is not a treatment protocol and no experimental treatments are involved. Study participants may be seen as needed for clinical…
Modeling Genetic Diversity in Sickle Cell Disease Reveals Heterogeneous Responses to HbF-Inducing Therapies
Abstract Sickle cell disease (SCD) is caused by a point mutation in the β-globin gene that promotes hemoglobin polymerization, leading to chronic hemolytic anemia, vaso-occlusive…
The Journey of Gene Therapy in Sickle Cell Disease: How Molecular Advances Meet Clinical Care
Highlights What are the main findings? Gene therapy for sickle cell disease has progressed from lentiviral gene addition strategies to precise genome editing approaches targeting…