Sickle Cell Disease news and research updates
Research readouts, treatment and access decisions, and community updates for people living with sickle cell disease and the people who care for them — each one dated, with a link to the original source where there is one.
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Orbital involvement in sickle cell disease: A systematic review
ABSTRACT Orbital involvement in sickle cell disease (SCD) is rare but potentially vision-threatening and often misdiagnosed due to overlap with infectious orbital disease. We…
Ten-Year Study Links Hydroxyurea Use to Reduced Mortality and Hospitalizations in Sickle Cell Patients
A ten-year study has identified significant clinical outcomes for patients with sickle cell anemia treated with hydroxyurea, including reduced mortality rates, fewer…
Life-changing benefits of hydroxyurea for sickle cell anemia affirmed by 10-year study
These are the benefits documented from 10 years of continuous hydroxyurea treatment provided in the NOHARM trial to a group of young children in Uganda, which has one of the…
Accurate identification of sickle cell disease cases in a large genotyped cohort using electronic health record data
Abstract The US Food and Drug Administration recently approved sickle cell disease (SCD) gene therapies that require a contemporaneous cohort to compare their outcomes with those…
Haploidentical transplant, gene therapy, and standard care in sickle cell disease: a cost-effectiveness analysis
Key Points Non-myeloablative haploidentical (NMAC-HID) transplant would be cost-effective for long-term SCD remission in adults Maximum gene therapy price versus standard care…
In Utero Gene Therapy for Sickle Cell Disease: Current Evidence, Ethical Considerations, and Future Directions—A Scoping Review
Abstract Purpose Sickle Cell Disease (SCD) is a monogenic, autosomal recessive disorder caused by mutations in the β-globin gene, resulting in the production of abnormal…
Elevated levels of hormone EPO tied to risk of blood clots in SCD: Large study
Higher blood levels of erythropoietin (EPO), a hormone that stimulates the production of red blood cells, increase the risk of blood clot-related, or thrombotic, events in people…
Cost-Effectiveness of Sickle Cell Transplant vs Gene Therapy
Summary Question This study analyzed the cost-effectiveness of three treatment strategies for sickle cell disease (SCD): standard care (SOC), gene therapy (GT), and…
Renin-Angiotensin-Aldosterone System Inhibition Exacerbates Anemia in Sickle Cell Disease
Abstract Renin-angiotensin-aldosterone system inhibitors (RAASi) are suggested for treating albuminuria in patients with sickle cell disease (SCD). RAASi may exacerbate anemia in…
Emerging concepts in sickle cell disease acute chest syndrome
Abstract Sickle cell disease (SCD) is a globally prevalent inherited hemoglobinopathy marked by chronic hemolysis, vaso-occlusion, and systemic inflammation, leading to…
Prevalence of Alloantibodies in Sickle Cell Disease and its Impact in Low-Resource Countries
Abstract Alloimmunisation is a notorious dilemma in blood transfusion intervention therapy, especially in low-resource countries, and studies have shown that individuals with…
Evaluating the Diagnostic Performance of AI and Machine Learning in Sickle Cell Disease Detection: A Systematic Review
Abstract Sickle cell disease (SCD) is a major global health burden, and early, accurate diagnosis is critical for effective management. Conventional diagnostic methods are often…