Sickle Cell Disease news and research updates
Research readouts, treatment and access decisions, and community updates for people living with sickle cell disease and the people who care for them — each one dated, with a link to the original source where there is one.
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Exercise in Sickle Cell Disease: The Impact on Pathophysiology and Clinical Symptoms
Abstract Sickle cell disease (SCD) is one of the most common inherited blood disorders worldwide. Clinical manifestations are variable, but include hyposplenism, renal impairment…
Vascarta Announces Phase I Results of VAS-101 Administered Sublingually in Sickle Cell Disease Patients
SUMMIT, N.J. , June 24, 2026 /PRNewswire/ -- Vascarta Inc., a clinical-stage biopharmaceutical company advancing innovative treatments for pain and inflammation, announced today…
Mitapivat raises hemoglobin levels in Phase 3 sickle cell disease trial
Agios Pharmaceuticals ’ medication mitapivat rapidly increased levels of the oxygen-carrying protein hemoglobin in patients ages 16 and older with sickle cell disease (SCD), while…
Agios Showcases RISE UP Phase 3 Results at EHA 2026 Plenary Session Reinforcing Strong Anti-Hemolytic Profile of Mitapivat in Sickle Cell Disease
Mitapivat demonstrated statistically significant improvement in hemoglobin response compared with placebo, with rapid onset and durable effects New analyses showed patients in…
Mitapivat Improves Anaemia in Sickle Cell Disease: EHA 2026
MITAPIVAT significantly improved haemoglobin levels and markers of haemolysis in patients with sickle cell disease (SCD) in a Phase 3 trial, with additional clinical benefits…
CURRENT CLINICAL TRIALS FOR NEW THERAPIES IN SICKLE CELL DISEASE DO NOT ADEQUATELY REPRESENT THE PATIENT POPULATION
Background: Sickle cell disease (SCD) is a progressive disorder characterized by acute pain crisis (APC), organ damage, and early mortality. Despite the (few) disease-modifying…
Sickle Cell, Thalassaemia and Red Cell Disorder Service
We are a specialist centre for the diagnosis and management of adults with inherited haemoglobin disorders including sickle cell disease, thalassaemia. Who we see We see patients…
Teen with Sickle Cell Disease, Headache and Forehead Swelling
Introduction Sickle cell disease (SCD) is the most common inherited blood disorder in the USA and globally, with a gradual increase in prevalence (1). SCD continues to impose a…
Severe maternal morbidity according to sickle cell disease genotype
Abstract Background Sickle cell disease (SCD) is a genetic hemoglobinopathy that disproportionately affects individuals of African descent and is associated with elevated risks of…
Gene-editing therapy frees first trial participant from SCD symptoms
A patient with severe sickle cell disease (SCD) remained free of two key SCD symptoms — including painful vaso-occlusive crises — for more than a year after receiving a single…
Nonmyeloablative HLA-identical sibling transplant for sickle cell disease in children: a multicenter prospective study
Abstract HLA-identical sibling donor hematopoietic cell transplant (HCT) is an established curative therapy for sickle cell disease (SCD). Although myeloablative HCT conditioning…
Sickle Cell Disease: Historical Overview and Current Therapies
Abstract Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry…