Sickle Cell Disease news and research updates
Research readouts, treatment and access decisions, and community updates for people living with sickle cell disease and the people who care for them — each one dated, with a link to the original source where there is one.
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Elevated Cerebral Blood Flow in Distal and Intermediate Arterial Territories in Pediatric Sickle Cell Anemia
Abstract Children with sickle cell anemia (SCA) are at increased risk of cerebrovascular complications due to chronic anemia and progressive vascular injury, yet how their…
Mandibular infarction and sterile subperiosteal fluid collection in patients with sickle cell disease: a report of two cases
Abstract Vaso-occlusive crisis is the primary cause of morbidity and emergency department visits in patients with sickle cell disease (SCD) and may lead to acute bone infarction…
A prospective study of high-impact chronic pain in sickle cell disease: the Sickle Pain-Related Impact (SPiRIt) study
Risk factors and outcomes of high-impact chronic pain (HICP), ie, chronic pain (CP) and substantial restriction of participation in work, social, or self-care activities, are not…
FDA Expands Use of First Sickle Cell Disease Gene Therapy for Children as Young as 2 Years
WEDNESDAY, July 8, 2026 (HealthDay News) -- The U.S. Food and Drug Administration has issued a supplemental approval for Casgevy (exagamglogene autotemcel) for patients aged 2…
Nanotechnology-Based Detection of Sickle Cell Disease and Thalassemia: A Systematic Review
Abstract Sickle cell disease (SCD) and thalassemia are genetic disorders that necessitate accurate diagnosis for effective management and improved patient outcomes. The advent of…
Subtotal Versus Total Splenectomy in Children With Sickle Cell Disease: Clinical Outcomes and Splenic Function Assessed by Pocked Red Blood Cell Count
The spleen is one of the first organs injured in sickle cell disease (SCD) [ 1 ]. Splenic impairment in SCD children can silently progress toward functional asplenia, exposing…
Efficacy of curcumin and resveratrol in the synergistic activation of foetal haemoglobin in sickle cell disease
Abstract Background and objectives Sickle cell disease is a major haemoglobin disorder, and foetal haemoglobin (HbF) remains the strongest modifier of disease severity…
Coping Strategies and Social Support for Transition Readiness Among Youth With Sickle Cell Disease
Abstract Importance: Suboptimal transitions from pediatric to adult health care can negatively impact disease outcomes, medication regimen adherence, and disease self-management…
Curcumin-based gel may ease sickle cell pain, early data suggest
A low dose of Vascarta ‘s VAS-101, a curcumin-based gel being developed for sickle cell disease (SCD), was well tolerated and showed early signs of reducing red blood cell…
NMAC-HID Allo-HSCT May Be More Cost Effective for SCD
For adults with sickle cell disease (SCD), a cost-effectiveness analysis suggests that treatment with nonmyeloablative haploidentical (NMAC-HID) allogeneic stem cell…
CS-206 Seems Safe and Effective in SCD, Patient Data Suggests
The first patient with sickle cell disease (SCD) treated with the base-editing therapy CS-206 in China remained free of vaso-occlusive crises for over 15 months, according to a…
Transplant outperforms standard care for children with sickle cell
Children with sickle cell anemia, the most common and severe form of sickle cell disease (SCD), who undergo stem cell transplant experience better long-term cognitive function…