Sickle Cell Disease news and research updates
Research readouts, treatment and access decisions, and community updates for people living with sickle cell disease and the people who care for them — each one dated, with a link to the original source where there is one.
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Cochlear Implantation in Sickle Cell Disease: A Systematic Review of Feasibility and Outcomes
Abstract Introduction: Sickle cell disease (SCD) is associated with systemic complications, including sensorineural hearing loss (SNHL) from microvascular occlusion and chronic…
Twice-Daily Deferiprone Well Tolerated in Real-World Anemia Clinical Practice
Twice-daily (BID) deferiprone (DFP) appeared well-tolerated in a real-world study that included patients with thalassemia, sickle cell disease (SCD) , or other anemias and…
The Battle For Sickle Cell
I wrote here a couple of years ago about the problems being experienced by Bluebird Bio, pioneers in commercializing human gene therapies. The summary is that despite getting…
Design, rationale, and baseline patient characteristics for the Sickle Cell Disease and CardiovAscular Risk - Red cell Exchange (SCD-CARRE) trial
HIGHLIGHTS SCD-CARRE is the first randomized controlled trial to compare chronic red blood cell exchange transfusion to standard of care in high-risk adults with sickle cell…
Distinct dendritic cell subsets are associated with immune dysfunction and clinical severity in sickle cell anemia
Abstract Sickle cell anemia (SCA) is characterized by chronic hemolysis, vaso-occlusion, sustained inflammation, immune dysfunction, and increased susceptibility to infections…
- Clinical Trials and Researchsicklecellanemianews.com
Doubling Down on Sickle Cell Disease
For a condition that affects millions worldwide, treatment progress for sickle cell disease (SCD) has been slow. In the United States alone, an estimated 100,000 people are living…
Sickle cell disease knowledge, attitudes, and management practices among nurses in northern Ghana: a cross-sectional study
Background Sickle cell disease (SCD) is a global public health concern with high morbidity and mortality among children, particularly in low-and-middle-income countries. Affected…
Growth and puberty in African children with sickle cell anemia treated with hydroxyurea
Abstract Children with sickle cell anemia (SCA) have poor growth and pubertal development. REACH (Realizing Effectiveness Across Continents with Hydroxyurea) is a prospective…
Sickle Cell Anemia with Complex Alloimmunization
Abstract Background: Sickle cell anemia is an autosomal recessive disorder caused by abnormal hemoglobin S, which polymerizes when deoxygenated and distorts erythrocytes into…
Feasibility and Implementation of a Group Therapy Program for Adults Living With Chronic Pain and Sickle Cell Disease
Abstract Adults living with sickle cell disease (SCD) experience high rates of chronic pain, depression, and anxiety, which significantly impair quality of life. Despite this…
Toward Health Care Structure–Informed Measures of Transition Success for Young Adults With Sickle Cell Disease
In 2010, analysis of the Dallas Newborn Cohort established a new reality for sickle cell disease (SCD): more than 90% of affected infants born after 1983 survive to adulthood. 1…
Predictors of nephropathy in sickle cell disease: A cross-sectional analysis across age and clinical phenotypes in Zaria, Nigeria
Abstract Background: Sickle cell disease (SCD) is associated with significant complications, including nephropathy, which can progress to end-stage renal disease. While risks for…