Sickle Cell Disease news and research updates
Research readouts, treatment and access decisions, and community updates for people living with sickle cell disease and the people who care for them — each one dated, with a link to the original source where there is one.
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Immune Imbalance in Sickle Cell Anemia: Flow Cytometric Insights Into Regulatory T Cells and Neutrophil Dynamics
ABSTRACT Objective To investigate immunophenotypic alterations in regulatory T cells (Tregs) and neutrophil dynamics in adult sickle cell anemia (SCA) patients during painful…
High early mortality among Ugandan children with sickle cell anemia and congenital HIV identified by newborn screening
The Uganda Sickle Surveillance Study (US3) documented sickle cell anemia (SCA) throughout the country. An important corollary was identification of infants born with SCA and…
Opioid use stigma may underlie clinician biases towards patients with sickle cell disease
In season 1, episode 2 of the popular show The Pitt, a Black woman with sickle cell disease arrives at the emergency department in acute pain, only to be initially dismissed as…
Genetically Modified Cell Therapy Reduces Severe Vaso-occlusive Crises in Patients With SCD
Treatment with ristoglogene autogetemcel (risto-cel) cell therapy led to rapid engraftment, improved fetal hemoglobin (HbF) expression, and reduced vaso-occlusive crises in…
Assessment of Haptoglobin, Creatinine and Novel Markers of AKI in Homozygous and Heterozygous Sickle Cell Disease Patients in Ekiti State.
Sickle cell disease (SCD) is characterised by the polymerisation of haemoglobin S (HbS) under low oxygen conditions, causing red blood cells to become rigid and sickle-shaped. The…
Lived Experiences of Patients With Sickle Cell Disease and Kidney Failure: Insights From a Qualitative Study
Abstract Patients with sickle cell disease (SCD) experience multisystem complications, with sickle cell nephropathy being a major contributor to chronic kidney disease and kidney…
Rewriting the Hemoglobin Switch: CRISPR Targeting in Sickle Cell Disease
The RUBY trial demonstrates that disrupting the BCL11A binding site in the γ-globin promoters can normalize hemoglobin in severe sickle cell disease. Background: The Problem Is…
Beam to seek OK of gene-edited cell therapy risto-cel for sickle cell disease
The BEACON clinical trial showed therapy's lasting benefits in 31 patients Beam Therapeutics plans to ask the U.S. Food and Drug Administration (FDA) to approve ristoglogene…
Efficacy of Automated Red Cell Exchange for Sickle Cell Disease: A Cross-Sectional Study
Background: Sickle cell disease is a hereditary hemoglobinopathy commonly seen in sub-Saharan Africa, India, and the Middle East. It is caused by a mutation in the β-globin gene…
Cost-Effectiveness of Routine Outpatient Follow-Up Intervals in Adults with Sickle Cell Anemia: A Pilot Study from Cameroon
Ngoe Samuel Bakia Department of Pharmaceutical Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Cameroon. Chetcha Bernard Chenmagni Department of…
Clinical Trial Shows Promise of a Functional Cure for Sickle Cell Disease
Gene therapy eliminated pain and improved blood counts in most patients with sickle cell disease in a major trial. New results from a clinical trial show promising outcomes for a…
Gene Editing Therapy Shows Success Against Severe Sickle Cell Disease
New results from a clinical trial show promising outcomes for a gene-edited treatment for severe sickle cell disease , a genetic blood disorder with few curative options…