Sickle Cell Disease news and research updates
Research readouts, treatment and access decisions, and community updates for people living with sickle cell disease and the people who care for them — each one dated, with a link to the original source where there is one.
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HSCT Shows Curative Potential in Adults With Sickle Cell Disease
Hematopoietic stem cell transplantation (HSCT) is both possible and effective in adult patients with sickle cell disease (SCD), according to a retrospective single-center study…
Etavopivat Phase 3 results support potential approval in sickle cell disease
A global, late-stage clinical trial testing etavopivat in people with sickle cell disease (SCD) has hit its main goals, showing that the experimental oral therapy improved…
Clinical Outcomes of Lentiviral Vector Gene Therapy for Sickle Cell Disease
Sickle cell disease (SCD) is a monogenic disorder where autologous gene therapy may offer a safer curative alternative to allogeneic transplantation. We report outcomes from a…
Sickle cell vaso-occlusive episodes correlate with the magnetic heterogeneity of red blood cells
Sickle cell disease (SCD) is a complex condition that results in low oxygen affinity and oxidative damage within red blood cells (RBCs), which contributes to serious complications…
Serum Vitamin A levels in children with sickle cell anemia: relationship with pulmonary function indices
Abstract Background Vitamin A is involved in the proliferation and maintenance of the epithelial cells of the respiratory tract. Since maintenance of the integrity of the…
Novo Nordisk to seek oral sickle cell therapy approval after Phase III victory
APhase III trial of Novo Nordisk’s once-daily tablet has met both co-primary endpoints, reducing vaso-occlusive crises (VOC) and increasing haemoglobin (Hb) response in patients…
High-Altitude Hypoxemia in Adults With Sickle Cell Disease (SCD
Sickle cell disease (SCD) is characterized by abnormal polymerization of deoxygenated hemoglobin S. This polymerization leads to the distinctive sickling of red blood cells (RBC)…
Gene Therapy and CRISPR-based Intervention in Sickle Cell Anemia
ABSTRACT: Sickle cell anemia is a severe inherited blood disorder caused by a mutation in the beta globin gene, leading to the formation of abnormal hemoglobin S and deformation…
Doctors More Likely to Use Negative Terms for Sickle Cell Patients
Sickle cell patients are more likely than other patients to have negative descriptions in their medical charts, such as “noncompliant” and “noncooperative,” according to a new…
- Clinical Trials and Researchpmc.ncbi.nlm.nih.gov
Movement behavior in adults with sickle cell disease compared to healthy adults: a cross-sectional study
Abstract Background Sickle cell disease (SCD) is one of the most common monogenic disorders in the world. Patients with SCD have chronic hemolytic anemia and experience episodic…
Evaluation of Implementation of Newborn Screening for Sickle Cell Disease Program in Selected Hospitals in Dar es Salaam, Tanzania
Department of Development Studies, School of Public Health and Social Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam P.O. Box 65001, Tanzania 2 Sickle…
An Ayurvedic management of the Sickle Cell Anaemia: A Case Study
Abstract Sickle Cell Anaemia is a genetic disease-causing high morbidity and mortality. Quality of life hampers due to its chronic nature and painful crisis. Permanent cure is not…