Sickle Cell Disease news and research updates
Research readouts, treatment and access decisions, and community updates for people living with sickle cell disease and the people who care for them — each one dated, with a link to the original source where there is one.
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How scientists made the discoveries behind a game-changing gene therapy for sickle cell disease
Sickle cell disease is the scourge of a person’s red blood cells. The inherited blood disorder, which disproportionately affects people in sub-Saharan Africa and India, can cause…
Novel use of a hash-based tokenization for sharing sickle cell disease data without sharing protected health information
Key Points This is the first SCD project to implement a privacy-preserving technique for linking individuals across multiple registries. Linkage of multiple registries enables…
Gene based therapy for sickle cell disease in low and middle income countries insights from the Gambia
Article summary Sickle Cell Disease (SCD) poses a significant health challenge in low- and middle-income countries, particularly in sub-Saharan Africa, where access to effective…
Kidney Function Decline in Sickle Cell Disease: Associations with Renin-Angiotensin System Inhibitors
Abstract Key points: Renin-angiotensin system inhibitor use was not associated with slowed GFR decline in sickle cell disease. This null association did not change after excluding…
Newborn screening results for sickle cell disease from the ASH Consortium on Newborn Screening in Africa (CONSA)
The Consortium on Newborn Screening in Africa (CONSA), launched by the American Society of Hematology in 2020, is designed to initiate and expand sustainable newborn screening…
Geographic and Temporal Differences in Sickle Cell Disease Hospitalizations in New York State
Abstract Importance: Sickle cell disease (SCD) disproportionately affects racial and ethnic minority groups in the US and is associated with high levels of morbidity and health…
BMC Researcher Aims to Build More Options, Access for Sickle Cell Disease Treatment
Sickle cell disease (SCD) is one of the most common inherited blood disorders worldwide, impacting millions of people globally and most commonly affecting individuals of African…
Hydroxyurea Optimisation in Sickle Cell Disease (PHOENIX-NG)
The wide interindividual variability in clinical response to hydroxyurea therapy in the management of sickle cell disease has limited its use. These variabilities have been linked…
Determinants of clinical severity in children with sickle cell disease and confirmed asthma
Abstract Background Asthma is a frequent comorbidity in children with sickle cell disease and has been associated with an increased risk of acute complications, particularly…
Multidrug Toxicity During Acute Painful Crises in Sickle Cell Diseases
Abstract Background: Hydroxyurea and red blood cells (RBC) transfusions prolong survival in sickle cell diseases (SCD). Methods: All patients were included. Results: We studied…
Decoding thalassemia and sickle cell disease: advances in molecular technologies for comprehensive variant detection
Abstract Thalassemia and sickle cell disease are inherited hemoglobinopathies caused by pathogenic variants in the globin genes and represent a major global health burden. Despite…
An Investigation comparing clinicians’ knowledge of Sickle Cell Disease
Introduction: Sickle Cell Disease (SCD) is a common inherited haemoglobinopathy with significant oral and systemic implications. Despite its prevalence in multi-ethnic populations…