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Sickle Cell Disease clinical trials near you

A clinical trial is a research study that tests whether a treatment is safe and works. Taking part is always your choice, and you can stop at any time. Listing a study here is not a recommendation — talk it through with your own team.

138 recruiting studiesFrom ClinicalTrials.gov (opens in a new tab)

Trial results

8 shown of 138

8 shown of 138 clinical trials.

  1. RecruitingObservationalNCT06071377

    Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)

    Sickle Cell Trait

    The main purpose of this study is to create a longitudinal cohort of those with Sickle Cell Trait (SCT) to better understand the hematologic phenotype for those that carry HbS, assess for differences in those with varying quantities of HbS and assess for potential clinical complications of SCT.

    Sites
    8
    Target
    1,000
    Study sites
    Birmingham, US +7 more

    Sponsor: National Alliance for Sickle Cell Centers

    View on ClinicalTrials.gov(opens in a new tab)
  2. RecruitingInterventionalNCT06650813

    Adapting the FACETS Program to Sickle Cell Disease

    Sickle Cell Disease, Fatigue Symptom

    Adaptation of a fatigue management program combining the principles of cognitive-behavioral therapy and energy conservation strategies (FACETS program) for a population of adult patients with sickle cell disease (Drépa-FACETS program).

    Sites
    2
    Target
    24
    Study sites
    Grenoble, FR +1 more

    Sponsor: Versailles Hospital

    View on ClinicalTrials.gov(opens in a new tab)
  3. RecruitingInterventionalNCT06770010

    Advancing Feasibility and Acceptability of Digital Cognitive Rehabilitation in Sickle Cell Disease

    Sickle Cell Disease

    This is a single site nonrandomized pilot clinical trial of the feasibility, acceptability, and efficacy of a combination treatment involving digital Cogmed working memory skills training, social support components, and memory strategy training to improve adherence to Cogmed in youth with sickle cell disease ages 7-16 years.

    Sites
    1
    Target
    50
    Study sites
    Washington D.C., US

    Sponsor: Children's National Research Institute

    View on ClinicalTrials.gov(opens in a new tab)
  4. RecruitingPhase 2InterventionalNCT06016634

    Alendronate for Osteonecrosis in Adults With Sickle Cell Disease

    Sickle Cell Disease, Sickle Cell Anemia, Osteonecrosis, Ischemic Necrosis, Avascular Necrosis

    A prospective, single-arm, intervention study of oral alendronate in adults with sickle cell disease and osteonecrosis

    Sites
    1
    Target
    30
    Study sites
    Sacramento, US

    Sponsor: University of California, Davis

    View on ClinicalTrials.gov(opens in a new tab)
  5. RecruitingPhase 1, Phase 2InterventionalNCT02447874

    Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease

    Sickle Cell Disease

    The purpose of this study is to determine whether giving extra arginine to patients with sickle cell disease seeking treatment for vaso-occlusive painful events (VOE) will decrease pain scores, decrease need for pain medications or decrease length of hospital stay or emergency department visit.

    Sites
    2
    Target
    21
    Study sites
    Atlanta, US +1 more

    Sponsor: Emory University

    View on ClinicalTrials.gov(opens in a new tab)
  6. RecruitingInterventionalNCT07562451

    Assessing Molecular Mechanisms and Effects of Music Therapy in Youth With Sickle Cell Disease Using Single-cell RNA-sequencing

    Sickle Cell Disease

    The goal of this clinical trial is to evaluate whether a 4-week music therapy (MT) intervention can reduce chronic pain and improve psychosocial outcomes in youth with sickle cell disease (SCD). The main questions it aims to answer are: * Does MT reduce pain intensity, frequency of pain episodes, and improve health-related quality of life (HRQoL)? * Does MT alter immune cell composition and gene expression in inflammatory pathways, as measured by single-cell RNA sequencing (scRNA-seq)? Researchers will compare participants randomized to music therapy versus a control condition to see if MT produces superior improvements in pain and psychosocial outcomes, and distinct molecular changes.

    Sites
    1
    Target
    25
    Study sites
    Atlanta, US

    Sponsor: Emory University

    View on ClinicalTrials.gov(opens in a new tab)
  7. RecruitingObservationalNCT00542230

    Blood Sampling for Research Related to Sickle Cell Disease

    Sickle Cell Trait, Sickle Cell Disease, Sickle Cell Anemia

    This study will collect representative blood samples from healthy children and adults and from children and adults who have unique red blood cell features that are related to sickle cell disease. Sickle cell disease is a blood disease that limits the ability of red blood cells to carry oxygen throughout the body. The purpose of the study is to collect a variety of blood samples that may then be used to investigate advances and potential new drug treatments for sickle cell disease. Volunteers must be at least 18 years of old. Samples will be taken both from healthy volunteers and from volunteers who have unique red blood cell features that are related to sickle cell disease. Candidates will be screened with a medical history. During the study, participants will undergo a one- to two-hour outpatient procedure at the National Institutes of Health Clinical Center. Once researchers have explained the study and obtained the participant s consent, participants will donate 8 cc (approximately 2 teaspoons) of blood. Because repeat testing helps researchers validate study findings, participants who have the unique red blood cell features mentioned above may also be asked if they are willing to return and donate another 2 cc to 8 cc of blood for additional studies. The amount of blood drawn will not exceed 50 ml with any eight-week period for adults or 7 cc within any six-week period for children....

    Sites
    1
    Target
    250
    Study sites
    Bethesda, US

    Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    View on ClinicalTrials.gov(opens in a new tab)
  8. RecruitingObservationalNCT07083531

    Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait

    Sickle Cell Disease, Sickle Cell Trait

    This is a cross-sectional, clinical research study comparing postmenopausal women of African Descent (AD) with different hemoglobin genotypes: normal and sickle cell trait (SCT). This research study has two purposes. The first purpose is to determine whether having SCT is a risk factor for the development of bone thinning in older women. The second purpose is to investigate whether women with SCT have reduced muscle function and increased frailty compared to women without SCT. The investigators estimate enrolling 50 female volunteers who are at least 50 years old and have not had a menstrual period for at least 12 consecutive months. Volunteers need not know whether they have SCT as this will be evaluated as part of the study.

    Sites
    1
    Target
    50
    Study sites
    Farmington, US

    Sponsor: UConn Health

    View on ClinicalTrials.gov(opens in a new tab)