Sickle Cell Disease | A Clinical Medicine Brief

In this episode of the HEME101 series from the Pro-PA Podcast, Dr. G breaks down Sickle Cell Disease (SCD)—a classic inherited hemoglobinopathy and one of the highest-yield hematology topics for the PANCE, PANRE, pediatrics, emergency medicine, and internal medicine board review.  

Sickle cell disease is caused by a mutation in the beta-globin gene, producing abnormal hemoglobin S (HbS) that polymerizes under low-oxygen conditions, causing red blood cells to become rigid, sickle-shaped, and prone to hemolysis and vaso-occlusion.