Respiratory syncytial virus and seasonal influenza cause similar illnesses in children with sickle cell disease | oneSCDvoice
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scientific articles

Respiratory syncytial virus and seasonal influenza cause similar illnesses in children with sickle cell disease

key information

source: Pediatric Blood & Cancer

year: 2014

authors: Sadreameli SC, Reller ME, Bundy DG, Casella JF, Strouse JJ

summary/abstract:

BACKGROUND:
Respiratory syncytial virus (RSV) is a cause of acute chest syndrome (ACS) in sickle cell disease (SCD), but its clinical course and acute complications have not been well characterized. We compared RSV to seasonal influenza infections in children with SCD.
PROCEDURE:
We defined cases as laboratory-confirmed RSV or seasonal influenza infection in inpatients and outpatients RESULTS:
We identified 64 children with RSV and 91 with seasonal influenza. Clinical symptoms, including fever, cough, and rhinorrhea were similar for RSV and influenza, as were complications, including ACS and treatments for SCD. In a multivariable logistic regression model, older age (OR 1.2 per year, 95% CI [1.02-1.5], P = 0.04), increased white blood cell count at presentation (OR 1.1 per 1,000/μl increase, 95% CI [1.03-1.3], P = 0.008), and a history of asthma (OR 7, 95% [CI 1.3-37], P = 0.03) were independently associated with increased risk of ACS in children with RSV. The hospitalization rate for children with SCD and RSV (40 per 1,000 CONCLUSIONS:
We conclude that RSV infection is often associated with ACS and similar in severity to influenza infection in febrile children with SCD.

organisation: Johns Hopkins University, Baltimore

DOI: 10.1002/pbc.24887

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