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scientific articles

Micronutrients and sickle cell disease, effects on growth, infection and vaso-occlusive crisis: a systematic review

key information

source: Pediatric Blood & Cancer

year: 2012

authors: Dekker LH, Fijnvandraat K, Brabin BJ, van Hensbroek MB


Patients with Sickle cell disease (SCD) exhibit signs of poor growth, increased susceptibility to infection and recurrent episodes of painful vaso-occlusive crises. Micronutrient deficiencies may increase susceptibility to these outcomes. We conducted a systematic review to assess the strength of evidence for improved outcomes related to micronutrient interventions. Six randomized-controlled trials of moderate quality met the inclusion criteria. Zinc supplementation was associated with improved growth and decreased incidence of infection and is a promising intervention in the management of SCD patients. Omega-3 fatty acid supplementation was associated with limited reduction in vaso occlusive crises. This review identifies key knowledge gaps, which are important research priorities for nutritional interventions.

organization: Academic Medical Center, Amsterdam, The Netherlands

DOI: 10.1002/pbc.24163

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