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scientific articles

Increase in invasive Streptococcus pneumoniae infections in children with sickle cell disease since pneumococcal conjugate vaccine licensure

key information

source: The Journal of Pediatrics 

year: 2011

authors: McCavit TL, Quinn CT, Techasaensiri C, Rogers ZR


Invasive pneumococcal disease (IPD) in children with sickle cell disease has decreased with prophylactic penicillin, pneumococcal polysaccharide vaccine, and pneumococcal protein-conjugate vaccine usage. We report 10 IPD cases since pneumococcal protein-conjugate vaccine licensure, including a recent surge of non-vaccine serotypes. IPD continues to be a serious risk in sickle cell disease.

organization: University of Texas Southwestern Medical Center at Dallas

DOI: 10.1016/j.jpeds.2010.11.025

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