Health Maintenance for People with Sickle Cell Disease: Evidence-Based Management of Sickle Cell Disease | oneSCDvoice
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guides & guidelines

Health Maintenance for People with Sickle Cell Disease: Evidence-Based Management of Sickle Cell Disease

key information

source: National Heart, Lung, and Blood Institute (U.S.)

year: 2014

summary/abstract:

Recommendations: Administer oral penicillin prophylaxis (125 mg for age <3 years and 250 mg for age >=3 years) twice daily until age 5 in all children with homozygous hemoglobin SS (HbSS). (Strong Recommendation, Moderate-Quality Evidence) Discontinue prophylactic penicillin in children with HbSS at age 5 unless they have had a splenectomy or invasive pneumococcal infection. When discontinuing penicillin prophylaxis at age 5, it is important to assure that the child has completed the recommended pneumococcal vaccination series, and if not, complete the series immediately. (Weak Recommendation, Moderate-Quality Evidence) Consider withholding penicillin prophylaxis from children with hemoglobin SC (HbSC) disease and HbSβ+-thalassemia unless they have had a splenectomy. (Weak Recommendation, Low-Quality Evidence) Assure that people of all ages with SCD have been vaccinated against Streptococcus pneumoniae.* (Strong Recommendation, Moderate-Quality Evidence) Remind people with SCD, their families, and caregivers to seek immediate medical attention whenever fever (temperature greater than 101.3°F or 38.5°C) occurs, due to the risk for severe bacterial infections. (Consensus–Panel Expertise)

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