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guides & guidelines

Guidelines for the management of acute pain in sickle-cell disease

key information

source: American Pain Society

authors: Lennette J. Benjamin, Carlton D. Dampier, Ada Jacox, Victoria Odesina, David Phoenix, Barbara S. Shapiro, Maureen Strafford, Marsha Treadwell


This guideline is the first comprehensive evidence-based guideline to address treatment of the pain of sickle-cell disease.

Its contents are:

Overview of Sickle-Cell Disease and Related Pain

Types and Characteristics of Pain Associated with Sickle-Cell Disease

Pain Assessment

Treatment of Pain in Sickle-Cell Disease

  • Pharmacological Management of Sickle Pain
  • Acetaminophen and NSAIDs
  • Opioids: Side Effects, Tolerance, Physical Dependence and Addiction
  • Drugs
  • Management of an Episode of Acute Pain
  • Details of Opioid Administration
  • Psychological, Behavioral, and Physical Interventions
  • Importance of Comprehensive Care
  • Sickle Pain in Developmental Stages
  • Focus of Care in Various Settings
organization: Albert Einstein College of Medicine, Bronx, NY; Marion Anderson Sickle Cell Center, Philadelphia; Wayne State University College of Nursing, Detroit; St. Francis Hospital, Hartford, CT; Appalachia State University, Boone, NC; Univ of Pennsylvania School of Medicine, Philadelphia; New England Medical Center, Boston; Children's Hospital Medical Center, Oakland, CA

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