• Join Today!

Become a member and connect with:

  • An Active Online Community
  • Articles and Advice on SCD
  • Help Understanding Clinical Trials
scientific articles

Acute silent cerebral infarction in children with sickle cell anemia

key information

source: Pediatric Blood & Cancer

year: 2010

authors: Dowling MM, Quinn CT, Rogers ZR, Buchanan GR


Silent cerebral infarctions (SCI) occur in up to 35% of children with sickle cell anemia (HbSS) but are rarely recognized during the initial 10-14 days when diffusion weighted magnetic resonance imaging (MRI) can differentiate acute infarctions from remote events. We report acute SCI in seven children with HbSS who had areas of restricted diffusion on MRI without persistent focal neurologic deficits. Four had acute SCI identified following acute anemic events. Our observations suggest that SCI are detectible in the acute phase, present with subtle neurologic symptoms, result in permanent neurologic injury, and may be caused by acute anemic events

organization: The University of Texas Southwestern Medical Center at Dallas

DOI: 10.1002/pbc.22242

read more full text source