• Join Today!

Become a member and connect with:

  • An Active Online Community
  • Articles and Advice on SCD
  • Help Understanding Clinical Trials
scientific articles

Acute myocardial infarction in sickle cell disease: a systematic review

key information

source: Critical Pathways in Cardiology

year: 2008

authors: Pannu R, Zhang J, Andraws R, Armani A, Patel P, Mancusi-Ungaro P


Myocardial infarction in young adults is, in practice, a diagnosis of exclusion. Given the fact that most of the patients with sickle cell disease are young and have predisposition to painful crisis, they are often overlooked for myocardial infarction. These patients often have few or no traditional risk factors for coronary artery disease, and risk stratification tools such as the Thrombolysis in Myocardial Infarction (TIMI) and Global Registry of Acute Coronary Events (GRACE) models place these patients at low risk. Nonspecific changes on electrocardiogram are of little diagnostic value. Myocardial infarction is very often a missed diagnosis in patients with sickle cell disease. Diagnostic criteria, potential mechanisms, and management for acute myocardial infarction in patients with sickle cell disease are discussed.

organization: New Hanover Regional Medical Center, Wilmington

DOI: 10.1097/HPC.0b013e3181668ac3

read more full text source